Muramidase Studies in Philadelphia-Chromosome-Positive and Chromosome-Negative Chronic Granulocytic Leukemia

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Abstract
Muramidasuria is most consistently demonstrated in acute monocytic leukemia. Detection of muramidasuria in some patients with chronic granulocytic leukemia led to a comparative study of 14 patients, demonstrating that the six patients with muramidasuria differed from the remaining eight patients in several ways. All were Philadelphia-chromosome negative. Serum muramidase levels were higher in the negative group, and the patients were older, with male-sex predominating, platelet counts were lower, and responsiveness to busulfan was poorer than in the positive group.