Multiple Myeloma

Abstract
BENCE–JONES protein in the serum, sufficient to produce a visible precipitate at 56°C, is of rare occurrence. Review of the literature discloses no more than 20 such cases recorded since the initial report of this finding by Ellinger1 in 1899. Only 4 instances of serum precipitating at the 56°C. temperature utilized to inactivate the serum complement have been recorded in over 700,000 complement-fixation studies made in the serology laboratories of the Cleveland Clinic since its founding in 1921. During this time 162 cases of multiple myeloma have been observed in the Cleveland Clinic and the Cleveland Clinic Hospital.Apparently no . . .

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