PARL Leu262Val is not associated with fasting insulin levels in UK populations
Open Access
- 21 September 2006
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 49 (11) , 2649-2652
- https://doi.org/10.1007/s00125-006-0443-9
Abstract
PARL, the gene encoding presenilins-associated rhomboid-like protein, maps to chromosome 3q27 within a quantitative trait locus that influences components of the metabolic syndrome. Recently, an amino acid substitution (Leu262Val, rs3732581) in PARL was associated with fasting plasma insulin levels in a US white population (N=1031). This variant was also found to modify the positive association between age and fasting insulin. The aim of this study was to test whether these findings could be replicated in two UK population-based cohorts.Keywords
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