Ethnic Differences in Genetic Polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1
- 1 January 2004
- journal article
- review article
- Published by Japanese Society for the Study of Xenobiotics in Drug Metabolism and Pharmacokinetics
- Vol. 19 (2) , 83-95
- https://doi.org/10.2133/dmpk.19.83
Abstract
Metabolic capacities for debrisoquin, sparteine, mephenytoin, nifedipine, and midazolam, which are substrates of polymorphic CYP2D6, CYP2C19, and CYP3A, have been reported to exhibit, in many cases, remarkable interindividual and ethnic differences. These ethnic differences are partly associated with genetic differences. In the case of the drug transporter ABCB1/MDR1, interindividual differences in its transporter activities toward various clinical drugs are also attributed to several ABCB1/MDR1 genetic polymorphisms. In this review, the existence and frequency of various low-activity alleles of drug metabolizing enzymes as well as populational drug metabolic capacities are compared among several different races or ethnicities. Distribution of nonsynonymous ABCB1/MDR1 SNPs and haplotype frequency in various races are summarized, with the association of nonsynonymous SNPs with large functional alterations as a rare event.Keywords
This publication has 100 references indexed in Scilit:
- Haplotypes ofCYP3A4 and their close linkage withCYP3A5 haplotypes in a Japanese populationHuman Mutation, 2003
- Sex Is A Major Determinant of Cyp3a4 Expression in Human LiverHepatology, 2003
- Cloning and Tissue Distribution of a Novel Human Cytochrome P450 of the CYP3A Subfamily, CYP3A43Biochemical and Biophysical Research Communications, 2001
- Quantitative Analysis of Constitutive and Inducible CYPs mRNA Expression in the HepG2 Cell Line Using Reverse Transcription-Competitive PCRBiochemical and Biophysical Research Communications, 2000
- Interindividual Differences in Hepatic Expression of CYP3A4: Relationship to Genetic Polymorphism in the 5′-Upstream Regulatory RegionBiochemical and Biophysical Research Communications, 1999
- SXR, a novel steroid and xenobioticsensing nuclear receptorGenes & Development, 1998
- A novel mutant variant of the CYP2D6 gene (CYP2D617) common in a black African population: association with diminished debrisoquine hydroxylase activityBritish Journal of Clinical Pharmacology, 1996
- Genotype analysis of the CYP2C19 gene in the Japanese populationLife Sciences, 1996
- Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolismPharmacogenetics, 1993
- Racial Differences in Drug ResponseNew England Journal of Medicine, 1989