Antigen-induced suppression of the in vitro lymphocyte response to different antigens and mitogens.

  • 1 March 1972
    • journal article
    • Vol. 22  (3) , 441-56
Abstract
Certain concentrations of antigen stimulated DNA synthesis in sensitized human lymphocytes cultivated in vitro, higher and lower concentrations being less stimulatory. The simultaneous addition of two antigens in low concentrations to the same cells caused an additive response. The decreased response to a high antigen dose did not affect the capacity of the cells to respond to the simultaneous addition of another antigen, as determined at the population level as well as at the cellular level by autoradiography. Presumably specific immunological paralysis was induced by high antigen doses.