ACID-CITRATE-DEXTROSE COMPARED WITH HEPARIN IN THE PREPARATION OF INVIVO INVITRO TECHNETIUM-99M RED-BLOOD-CELLS
- 1 January 1983
- journal article
- research article
- Vol. 24 (5) , 383-387
Abstract
Red blood cells [RBC] labeled in vivo/in vitro with 99mTc (99mTc RBC) were prepared in a series of 21 patients and two normal volunteers. In each subject both heparin and acid-citrate-dextrose (ACD) solutions were used to label tandem blood samples. The immediate preinjection binding efficiency (BE) was then determined. In each of the 23 studies, the ACD preparation yielded superior BE. The average BE was 93.47% (.+-. 3.78) with ACD and 87.23% (.+-. 4.29) with heparin. With the ACD method the effect of carrier 99mTc may be as great as a 24% reduction in BE observed when initial eluates from long-ingrowth-time generators were used. Improved image quality with minimal renal and urinary-bladder activity results with ACD labeling. The use of ACD apparently results in superior RBC labeling with less nontarget activity relative to heparin and is preferred over heparin for preparing in vivo/in vitro 99mTc RBC.This publication has 12 references indexed in Scilit:
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