Lowly Expressed Human MicroRNA Genes Evolve Rapidly
Open Access
- 19 March 2009
- journal article
- research article
- Published by Oxford University Press (OUP) in Molecular Biology and Evolution
- Vol. 26 (6) , 1195-1198
- https://doi.org/10.1093/molbev/msp053
Abstract
To study the evolution of human microRNAs (miRNAs), we examined nucleotide variation in humans, sequence divergence between species, and genomic clustering patterns for miRNAs with different expression levels. We found that expression level is a major indicator of the rate of evolution and that ∼30% of currently annotated human miRNA genes are almost free of selective pressure.Keywords
This publication has 22 references indexed in Scilit:
- Fast Evolution of Core Promoters in Primate GenomesMolecular Biology and Evolution, 2008
- Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genesRNA, 2005
- Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA TargetsCell, 2005
- The functions of animal microRNAsNature, 2004
- Aligning Multiple Genomic Sequences With the Threaded Blockset AlignerGenome Research, 2004
- MicroRNAsCell, 2004
- A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegansNature, 2003
- MicroRNA Pathways in Flies and WormsCell, 2003
- Vertebrate MicroRNA GenesScience, 2003
- dbSNP: the NCBI database of genetic variationNucleic Acids Research, 2001