Studies on the biochemistry of zinc. 3. Further investigations on the influence of zinc on metabolism

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Abstract
Changes in the metabolism of N, P, and S and in urinary excretion of uric acid and total creatinine (creatine and creatinine) in rats fed a high-fat diet supplemented with Zn were found similar to those observed with a stock diet. Decreased assimilation of phosphate from the intestines was not due to its precipitation as insoluble Zn phosphate. Zn supplements at the levels investigated affected the phosphatase activity of the tissues. The activity of intestinal alkaline phosphatase was lowered, but activity in the liver and kidneys was increased. Zn supplements lowered the fat content of the liver, but appeared not to change fecal fat. The influence of Zn and other substances, such as choline, methionine, L-cystine and cyanide on the lipolytic activity of pancreatic lipase of the rat was also investigated.