Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles
- 11 October 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 8 (23) , 5231-5234
- https://doi.org/10.1021/ol061975c
Abstract
A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expedite the chemical syntheses.Keywords
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