H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.

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Abstract
Fully allogeneic [mouse] chimeras developed in vitro alloantigen-specific and H-2-restricted Sendai virus-specific cytotoxic T lymphocyte (CTL) responses. Depending on the immunization regimen used, Sendai virus-specific CTL responses were restricted to the H-2 antigens of the stem cell donor or the thymus. Unprimed splenic T cells of normal mice contained CTL-precursor cells that specifically reacted against Sendai virus or trinitrophenyl derivatives in the context of allogeneic major histocompatibility complex determinants not encountered during their thymic differentiation. A frequency analysis of allogeneically vs. syngeneically restricted virus-specific CTL precursors present in splenic T cells showed a ratio of about 1 to 6. H-2 restriction of trinitrophenyl- or Sendai virus-specific T cells apparently is dictated by the complex type of the antigen-presenting cell and appears to be independent of the type of thymus in which the T cells underwent maturation.

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