Comparison of dual-photon absorptiometry systems for total-body bone and soft tissue measurements: Dual-energy X-rays versus gadolinium 153

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Abstract
A total of 81 subjects (41 males and 40 females) were scanned by dual‐photon absorptiometry by 153Gd source (DPA; Lunar DP4) and by dual‐energy x‐ray absorptiometry (DEXA; Lunar‐DPX) within a 24 h period. Total‐body bone mineral density (TBMD), calcium content (Ca), and soft tissue mass (ST) were determined with a precision of about 1–1.5% using DPA and 0.5–1.0% using DEXA. Measurements of TBMD, Ca, ST, bone area (area), percentage fat, and regional bone mineral densities (BMD) were compared. Paired t‐tests showed small but significant differences between all measurements. Correlations (r) for TBMD, Ca, area, ST, percentage fat, arm BMD, leg BMD, and trunk BMD were 0.99, 0.99, 0.97, 0.99, 0.97, 0.99, 0.99, and 0.98. There were small systematic differences for TBMD (<1%), calcium (3%), bone area (3%), soft tissue mass (7%), and percentage fat (9%) between the two approaches. Regression equations are given relating these measurements.
Funding Information
  • NIH (DK37352)