Genetic Linkage Analysis of Hemoglobin Variants in 175 Families

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Abstract
Linkage analysis using the LIPED program (Ott) for the analysis of whole family data was performed on 175 families with variants of the Hb .beta.- or .gamma.-chain. Comparison of results with those in the literature indicate that there is little evidence for linkage with any of the currently used markers, although there is considerable heterogeneity in lod scores between sexes for the Duffy and MNS blood groups. The most successful approach may be to analyze markers known to be localized on chromosomes which were indicated as likely sites of the .beta.-chain locus from hybridization studies.