Preliminary Studies of the Caries Inhibiting Potential and Acute Toxicity of Sodium Monoflltorophosphate

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Abstract
When admn. at a level of 40 ppm. of fluoride in the drinking water of Syrian hamsters, Na mono-fluorophosphate and NaF caused comparable and nearly maximal reductions in the destruction of tooth substance by dental decay. Na monofluorophosphate was found to be 7-8 times less toxic in 200- to 300-g. rats than was NaF. Calculated on the basis of fluoride content the complex fluoride is 2.5-3 times less toxic than the free ionic form. In view of the fact that the monofluorophosphate complex was apparently not appreciably hydrolyzed in the animal body, one may infer that F does not have to be in a free ionic form to inhibit dental decay in the Syrian hamster.

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