SYMPTOMS OF VIOSTEROL OVERDOSAGE IN HUMAN SUBJECTS

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Abstract
During the past five years there have been carried out in the department of physiology in the University of Illinois College of Medicine a number of fundamental investigations on the physiologic mechanisms involved in the action of vitamin D. The information derived from these and other investigations has suggested the therapeutic use of this substance in concentrated form in a number of clinical conditions. However, it is my purpose in this paper not to discuss the results of these investigations but to describe some of the results of overdosage. Consequently, the clinical results of overdosage will be discussed without particular regard to the conditions for which the administration was undertaken. A. F. Hess and Lewis,1 Bamberger and Spranger,2 Opitz,3 and J. H. Hess, Poncher, Dale and Klein4 have all described toxic conditions in children, and Laurens5 has reviewed the literature on toxicity in experimental animals