Failure of Liver Feeding to Counteract Cortisone Effects Other than Growth Inhibition

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Abstract
Desiccated liver powder as a dietary supplement to a low sodium diet is effective in counteracting the growth inhibition induced by cortisone acetate in rats only if the steroid is presented orally. It is without demonstrable effect in animals receiving the hormone by injection. It is also without effect in adrenalecto-mized animals, irrespective of the route of hormone administration. The prevention of growth inhibition by liver powder is not accompanied by other evidences of diminished cortisone activity, i. e., despite normal growth such animals exhibit physiological, anatomical and biochemical changes of the same degree as do cortisone treated rats without liver supplement.