Observations of Increased Levels of Blood Coagulation Factors and Other Plasma Proteins in Cholestatic Liver Disease

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Abstract
One group of 8 patients with primary biliary cirrhosis and 1 group of 7 patients with common duct stone both had generally high levels of blood coagulation factors and a wide range of other plasma proteins. In contrast, 1 group of 6 patients with chronic active hepatitis generally had low levels of the same coagulation factors and plasma proteins. Analyses of factor II-VII-X, plasminogen, ceruloplasmin, .beta.1C/1A-globulin, IgG (immunoglobin G) and IgM are especially helpful in the differentiation between primary biliary cirrhosis and chronic active hepatitis. There is an increased synthesis of liver-produced proteins in the cholestasis, although more specific factors may modify the degree of increase of the individual proteins.

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