Activation of 5‐HT3 receptor subtypes causes rapid excitation of rabbit parasympathetic neurones
Open Access
- 19 July 1987
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 91 (3) , 453-455
- https://doi.org/10.1111/j.1476-5381.1987.tb11236.x
Abstract
Intracellular recordings were made from parasympathetic neurones of the rabbit vesical pelvic ganglia maintained in vitro. 5-Hydroxytryptamine (5-HT) caused a membrane depolarization which was antagonized by ICS 205–930 ([3α-tropanyl]-1H-indole-3-carboxylic acid ester) but not by methysergide. ICS 205–930 caused a parallel shift to the right of the dose-response curve for 5-HT. These results suggest that the 5-HT3 receptor is involved in the membrane depolarization.This publication has 23 references indexed in Scilit:
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