FDA Approval of Coronary-Artery Brachytherapy

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Abstract
Recurrent coronary stenosis occurs in 20 to 30 percent of patients in whom stents have been implanted for the treatment of obstructive lesions; when it occurs within the stent, it is referred to as in-stent restenosis. Not only is such stenosis a challenging problem to treat, but recurrences occur in as many as 60 percent of patients who have been treated for in-stent stenosis. The magnitude of this health problem becomes apparent when one recognizes that stents are reportedly used in as many as three quarters of the approximately 700,000 percutaneous coronary angioplasty procedures performed annually in the United States. . . .