POSSIBLE INVOLVEMENT OF THE CENTRAL NERVOUS SYSTEM IN GRAFT REJECTION

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Abstract
Electrolytic lesions were produced in the tuberal hypothalamus and amygdala of male Fischer and female BNLF1 rats and in male Fischer and female BNLF1 rats than had received antecedent hypophysectomies. Skin grafts from Lewis rats survived less well on tuberal-lesioned male Fischer rats than similar grafts on sham-operated and amygdala-lesioned male Fischer rats. Lewis skin graft survival was also curtailed in male Fischer rats that had received hypophysectomies followed by tuberal lesions. These differences were not apparent across the male to female (H-Y) BNLF1 histocompatibility barrier. Tuberal hypothalamic lesions stimulate allograft reactivity in rats; this response is greater when the immunogenetic disparity between donor and host is greater. The mechanism governing this response involves a direct neural pathway which bypasses the hypothalamic-hypophyseal axis.