Inhibitory action of calcitonin gene-related peptide (CGRP) in the mouse colon
- 1 July 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 42 (7) , 520-521
- https://doi.org/10.1111/j.2042-7158.1990.tb06612.x
Abstract
The effect and mechanism of action of calcitonin gene- related peptide (CGRP) have been investigated on the mouse distal colon. CGRP caused a concentration-dependent relaxation which was not blocked by classical pharmacological antagonists. The response pattern was characterized by a relatively rapid onset and long sustained duration. The results suggest that CGRP itself may contribute to regulating the muscular tone of the mouse colon.This publication has 16 references indexed in Scilit:
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