ISONIAZID SUSCEPTIBILITY, CATALASE ACTIVITY, AND GUINEA PIG VIRULENCE OF RECENTLY ISOLATED CULTURES OF TUBERCLE BACILLI

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Abstract
A negative catalase test in a culture of tubercle bacilli is significant because it indicates a moderate to high degree of isoniazid resistance and the probability of attenuation of virulence for guinea pigs. An uncontaminated culture of acid-fast bacilli which gives a very strong catalase reaction should be suspected of being either a saprophyte or an "atypical" acid-fast strain.