SYNTHETIC CHELATING AGENTS IN IRON METABOLISM*

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Abstract
Three synthetic chelating agents, ethylenediamine di-(o-hydroxyphenylacetic acid, diethylenetriaminepentaacetic acid, and ethylenediaminetetraacetic acid, were shown to be less effective than transferrin in binding Fe in vitro. When injected intravenously they are distributed in the extracellular space and rapidly excreted. The Fe-chelate complex is partly dissociated in vivo and Fe is yieled to transferrin. Synthetic chelates do not participate significantly in normal Fe exchange between donor tissues, such as intestinal mucosa and reticuloendothelial cells, and the receptor cells of the erythroid marrow and do not remove Fe from transferrin. Chelates do bind Fe when present in plasma associated with proteins other than transferrin and bind noncirculating Fe in patients with Fe overload. In these 2 conditions the chelates may be useful in effecting excretion of Fe.

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