CORPUS LUTEUM STUDIES III. PROGESTERONE THERAPY IN CHRONIC CYSTIC MASTITIS

Abstract
Endocrine studies on cases of chronic cystic mastitis including 7 cases of mastodynia, 5 cases of adenosis or Schimmelbusch disease, and 4 cases of cystic disease along with 7 controls are reported. Pregnanediol detns. on the urine were carried out on all of the 23 patients and estrogen assays on 12. The endocrine disturbance in the 7 cases of mastodynia and in 5 cases of adenosis was similar, adenosis apparently being a more advanced stage of mastodynia. The pregnanediol values in both of these groups were low averaging 11.6 mg. per cycle as compared to 39.1 for the controls. Estrogen values may be normal. These cases may be looked upon either as having a corpus luteum deficiency or as having a relative hyper-estrinism. In 2 cases studied after cysts had developed both estrogen and pregnanediol values were low. In the cycle preceding the development of a cyst, pregnanediol output was normal and estrogen output high (2085 r. u.) in 1 case, and pregnanediol values normal in the 2d case.

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