Silica Gel Functionalised with Different Spacers as Solid Support for Oligonucleotide Synthesis
- 1 February 1988
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 7 (1) , 75-90
- https://doi.org/10.1080/07328318808068704
Abstract
The phosphotriester method for synthesis of oligonucleotides has been used for evaluating silica with spacer groups. Three different spacers were synthesized of which a long chain alkylamine, a double glycine and a double y-aminobutyric acid unit. Only the double glycine spacer improved the yields of the first condensations and is now routinely used in our laboratory.This publication has 17 references indexed in Scilit:
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