EXCRETION OF ADMINISTERED RADIOCALCIUM1FOLLOWING THYROPARATHYROIDECTOMY, OR BILATERAL NEPHRECTOMY, AND THE INJECTION OF PARATHYROID EXTRACT2

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Abstract
The urinary and fecal excretion of administered radiocalcium by rats during an 18-hr, period was detd. at intervals of 1-40 days after thyroparathyroidectomy. On an adequate diet, containing 1.18% of Ca and 0.98% of P, the urinary excretion of radiocalcium was unchanged, but the fecal excretion was diminished and remained below the control level for several days. Administered radiocalcium appeared to accumulate in the kidneys of thyroparathyroidectomized rats, injected with parathyroid extract, prior to the elevation of the serum Ca level, but the fractions of the injected radiocalcium excreted in the urine and feces were not increased. Normal rats injected with toxic doses of parathyroid extract showed an increased urinary excretion of the administered radiocalcium concomitant with a decreased fecal excretion. Bilaterally nephrectomized rats excreted smaller amts. of injected radiocalcium than their normal controls. The injn. of parathyroid extract in nephrectomized rats did not increase the fecal excretion of administered radiocalcium.