Gastric acid regulates the release of plasma secretin in man

Publisher Website
Google Scholar
Abstract
Fasting plasma secretin determined in nine healthy subjects, twelve patients with active duodenal ulcer and four with Zollinger‐Ellison syndrome were 3·2±0·4, 5·1±1·2 and 20·3±1·3 pmol/l respectively (mean ±SEM). Cimetidine significantly (PPP‐1 l‐1). Cimetidine reduced both rises (PP<0·001). These results suggest that gastric acid is a major release mechanism for plasma secretin both fasting and after meals but it is likely the acid load rather than absolute pH in the duodenum which determines circulating levels.