ENDOTHELIAL MORPHOLOGY RELATED TO DISEASE ACTIVITY IN HUMAN CORNEAS

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Abstract
Normal [20] and 4 groups of pathological corneas with aphakia, macula after herpetic keratitis, Fuchs'' endothelial dystrophy and graft rejection were stained with trypan blue and alizarin red. The morphology of the endothelium was described in terms of cell density, coefficient of variation for cell area, percentage of hexagonal cells, percentage of joint meetings of more than 3 cells, nuclei per cell and nuclear shape. The groups of aphakia, keratitis, Fuchs'' dystrophy and graft rejection apparently represent increasing degrees of endothelial disease activity at the time of evaluation. The only parameter showing consistent variation with disease activity was the percentage of joint meetings of more than 3 cells.