Evaluation of the Kveim Reaction as a Diagnostic Test for Sarcoidosis

Abstract
IN 1941 Kveim1 described a new skin reaction in which the intracutaneous injection of a homogenate of human sarcoidal tissue led to the formation of a nodule at the test site over the course of several weeks in patients with sarcoidosis, but not in normal subjects or persons with other diseases.Numerous investigators have subsequently studied this reaction, and most of them have supported the claim of its specificity for sarcoidosis.2 3 4 5 6 7 8 9 10 However, the dissenting opinion of one group of workers tended to cast some doubt on the validity of the Kveim test.11 , 12 This communication presents the results of a Cooperative . . .

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