A TRANSIENT MONOCLONAL HUMAN IGGLK PROTEIN WITH ANTI-THYROGLOBULIN ACTIVITY - LACK OF CROSS-IDIOTYPY WITH POLYCLONAL ANTI-THYROGLOBULIN ANTIBODIES

  • 1 January 1981
    • journal article
    • research article
    • Vol. 46  (2) , 268-276
Abstract
A female patient in her early 60''s had for a period of at least 4 mo. a monoclonal IgG1.kappa. protein in her serum and at the same time a very high level of anti-thyroglobulin antibodies. Different isolation procedures showed that the M component was responsible for the high anti-thyroglobulin activity. Anti-idiotypic antibodies raised in a rabbit against the monoclonal protein inhibited the M component''s anti-thyroglobulin activity; purified thyroglobulin blocked the reaction between the M component and the anti-idiotypic antiserum. After the M component had disappeared, no cross-idiotypic IG was detected in the patient''s serum; the anti-idiotypic antiserum did not inhibit the residual anti-thyroglobulin activity present in the serum at this time. No reaction was detected between the antiserum and the anti-thyroglobulin antibodies of sera of other patients. Idiotypic autoantibodies against the M component, which might have caused its disappearance, were not demonstrated.