Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control.
Open Access
- 1 December 1975
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 142 (6) , 1564-1569
- https://doi.org/10.1084/jem.142.6.1564
Abstract
Experimental amyloidosis in mice can be induced by repeated injections of casein. It has now been demonstrated that casein induces strong polyclonal antibody synthesis in mouse B spleen lymphocytes. This effect is much more pronounced in spleen cells from anyloid-susceptible mice (CBA/J) than amyloid-resistant mice (A/J). It is suggested that amyloidosis can be due in some instances to a constant exposure for molecules which induce polyclonal B-cell activation.Keywords
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