PRINCIPLES OF BLOOD SEPARATION AND COMPONENT EXTRACTION IN A DISPOSABLE CONTINUOUS-FLOW SINGLE-STAGE CHANNEL

  • 1 January 1979
    • journal article
    • research article
    • Vol. 54  (1) , 254-268
Abstract
A single-stage disposable channel and seal that provides for leukocyte and granulocyte collection by continuous-flow cell separation (CFCS) was designed by the IBM Corporation. The following topics were described: the separation characteristics of whole blood as it responds to varying gravitational (G) forces and flow rates through the channel; the mechanism by which the buffy coat accumulates and is extracted; the efficiency of extraction; those donor and procedural variables that contribute to the final yield; posttransfusion increment response in patients; and the functional integrity of the cells collected.