Whole Saliva Fluoride after Toothbrushing with NaF and MFP Dentifrices with Different F Concentrations

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Abstract
The present study was designed to assess the effect of F compound and F concentration in dentifrices on fluoride in whole saliva after ordinary toothbrushing. The dentifrices tested had the same basic composition and contained NaF: 500, 1,000 or 1,500 ppm F or MFP: 1,000 or 1,500 ppm F. Whole saliva samples were collected at different times up to 120 min after brushing with controlled amounts of dentifrice. With all dentifrices tested, total F in whole saliva remained higher than controls for more than 60 min. Total F and F–– levels showed a simple relationship to the F concentration in the dentifrices. The F–– levels were initially significantly lower with the MFP than with comparable NaF preparations, but 10 min after brushing similar F–– levels were observed with the two compounds. With the MFP dentifrices the proportion of F–– to total F increased from 4% after 0.5 min to about 65% after 10 min indicating that MFP was subjected to rapid hydrolysis in the oral environment.