THE STRUCTURE OF MYCOBACTIN P, A GROWTH FACTOR FOR MYCOBACTERIUM JOHNEI, AND THE SIGNIFICANCE OF ITS IRON COMPLEX
- 1 January 1965
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 94 (1) , 160-165
- https://doi.org/10.1042/bj0940160
Abstract
The growth factor from Mycobacterium phlei is now named mycobactin P to distinguish it from related but chemically distinct growth factors from other species of mycobacteria. It is shown to comprise four closely similar chemical entities differing only in the fatty side chain. The structure of the main component (85%) of mycobactin P has been established and the absolute configuration of all asymmetric centers determined. Ferric mycobactin P has been crystallized; its structure is discussed. Evidence is given for regarding ferric mycobactin P as a member of the class of compounds known as sideramines, though the mycobactins are more specialized than other sideramines.Keywords
This publication has 11 references indexed in Scilit:
- Amino-acid Sequences within the Ferrichrome Cyclic HexapeptidesNature, 1963
- Investigations on the Action of the Iron-Containing Growth Factors, Sideramines; and Iron-Containing Antibiotics, SideromycinsJournal of General Microbiology, 1963
- Bacterial iron metabolism: Investigations on the mechanism of ferrichrome functionArchives of Biochemistry and Biophysics, 1962
- [Sideramines, iron-containing growth factors from micro-organisms].1962
- Studies on the Metabolic Function of the Ferrichrome CompoundsJournal of Biological Chemistry, 1961
- Über eisenhaltige Wachstumsfaktoren, die Sideramine, und ihre Antagonisten, die eisenhaltigen Antibiotika SideromycineCellular and Molecular Life Sciences, 1960
- 'Iron Transport' Compounds as Growth Stimulators for Microbacterium sp.Journal of General Microbiology, 1959
- Some aspects of microbial iron metabolism.1957
- STUDIES ON THE ISOLATION AND NATURE OF THE 'TERREGENS FACTOR'Canadian Journal of Biochemistry and Physiology, 1954
- Mycobactin, a growth factor for Mycobacterium johnei. 1. Isolation from Mycobacterium phleiBiochemical Journal, 1953