Effect of Adrenalectomy and Hypophysectomy in Permeability of the Synovial Membrane in Rabbits.

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Abstract
Studies were carried out to determine the effects of adrenalectomy and hypophysectomy on permeability of the ground substance of the synovial membrane. Neither adrenalectomy nor hypophysectomy had marked effects on permeability in short term experiments. Of the compounds studied only cortisone acetate, DCA and hyaluronidase had unaltered effects on the permeability of the ground substance in the absence of the adrenals. Both 21-acetoxy pregnenelone and allopregnane 21-ol-3, 21 dione 21 acetate were shown to have 2 actions. The anti-permeability action probably resulted from stimulation of the adrenal cortex. The antagonism to DCA and hyaluronidase was probably due to effects on the ground substance.

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