IRON INCREASES COLLAGENASE PRODUCTION BY RABBIT SYNOVIAL FIBROBLASTS
- 1 January 1981
- journal article
- research article
- Vol. 97 (3) , 396-402
Abstract
Ionic iron, as the chelate FeNTA [ferric nitrilotriacetate] was taken up by rabbit synovial fibroblasts in monolayer culture. Uptake was accompanied by increased production of latent collagenase and PGE2 [prostaglandin E2]. Concomitant addition of deferrioxamine, a specific chelator of Fe3+, prevented iron uptake and induction of collagenase and PGE2. Collagenase induced by iron may have a role in the pathogenesis of certain disease states associated with abnormal iron deposition in joints.This publication has 10 references indexed in Scilit:
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