STEROID HORMONE FORMATION BY THE RAT OVARY.

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Abstract
Ovaries were transplanted to the spleens of spayed female rats. After 18 months, ovarian neoplasms had developed. Slices of two different ovarian tumours were incubated with 10 [mu]e acetate-1-C14. Radioactive steroid hormone formation was assessed quantitatively by the reverse isotone dilution technique. Tissue from one ovarian neoplasm, considered to be a luteoma, formed ratioactive progesterone and 20[alpha]-hydroxypregn-4-en-3-one. The formation of 3[beta]-hydroxy-pregn-5-en-20-one, androst-4-ene-3,17-dione, testerone, 30[beta] -hydroxy-androst-5-en-17-one, 17-hydroxy-pregn-4-ene-3,20-dione, oestrone and 17[beta] -oestradiol could not be established. No radioactive steroid hormone synthesis could be detected using granulosa cell tumour tissue.