THE RELATIONSHIP OF RENAL BLOOD PRESSURE AND BLOOD FLOW TO THE PRODUCTION OF EXPERIMENTAL HYPERTENSION

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Abstract
The application of a clamp upon the aorta above both renal artery orifices effected a reduction in the mean and pulse pressure within the renal artery with no apparent effect upon the renal blood flow. This procedure did reduce the degree of glomerular filtration. If the clamp was placed upon the aorta between both renal orifices, the same phenomena were observed. When the clamp was released the renal blood flow decreased about 20% although the glomerular filtration returned to normal within the kidney. This secondary renal ischemia occurred only when the clamp was placed upon the aorta above both renal artery orifices. In 5 dogs, when clamps were allowed to remain permanently upon the aorta above both renal artery orifices, a chronic hypertension occurred in all of them despite the fact that the renal blood flow did not decrease after the application of the aortic clamp nor did it decrease at the time of hypertension. These findings indicated that renal ischemia does not cause or maintain a renal hypertension.