Effect of Poly(D,L-lactide) Addition to 2-Cyanoacrylates on Their Physical Properties and Toxicity

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Abstract
Poly(D,L-lactide)'s (PLA) with different molecular weights were added to 2-cyanoacrylates (CA) to modify the physical properties of CA as a sur gical adhesive. The CA's used were ethyl 2-cyanoacrylate, isobutyl 2-cyano acrylate, and ethoxyethyl 2-cyanoacrylate. The viscosity and the set time of CA increased, and the bond strength reached a maximum, when the concentration of PLA with the molecular weight of 420,000 increased for the three CA's. To evaluate the toxicity of the mixtures, microspheres were prepared from the polymer of CA and PLA, and added to the medium for the culture of 3T3 cells. It was found that the PLA addition to ethoxyethyl 2-cyanoacrylate resulted in a decrease of the cell growth inhibition by the ethoxyethyl 2-cyanoacrylate polymer. Isobutyl 2-cyanoacrylate exhibited no significant inhibition on the 3T3 cell growth.