Biocompatibility testing of polymers: In vivo implantation studies
- 1 March 1978
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 12 (2) , 219-232
- https://doi.org/10.1002/jbm.820120207
Abstract
An in vivo method is described for screening polymeric materials for biocompatibility. The test is based on grading acute and subacute tissue reactions at 7 and 28 days, respectively, following implantation in rats. The method is reproducible and reliable. It is designed to provide uniform test criteria for biocompatibility assessment in the early phases of the development of surgical implant materials.This publication has 25 references indexed in Scilit:
- Biocompatibility testing of polymers: In vitro studies with in vivo correlationJournal of Biomedical Materials Research, 1978
- Studies of the stability and toxicity of zinc polyacrylate (polycarboxylate) cements (PAZ)Journal of Biomedical Materials Research, 1974
- The foreign body reaction—an experimental protocolJournal of Biomedical Materials Research, 1974
- Inflammatory reaction evoked by zinc polyacrylate and zinc eugenate cements. A comparisonBritish Dental Journal, 1972
- Mechanism of CalcificationClinical Orthopaedics and Related Research, 1971
- Sterilization problems of synthetic biocompatible materialsJournal of Biomedical Materials Research, 1971
- The effect of α‐cyanoacrylates on wound healingJournal of Biomedical Materials Research, 1969
- Toxicity profiles of vinyl and polyolefinic plastics and their additivesJournal of Biomedical Materials Research, 1968
- Determination of residual ethylene oxide in catheters by gas—liquid chromatographyJournal of Biomedical Materials Research, 1968
- Histotoxicity of Cyanoacrylate Tissue Adhesive in the RatAnnals of Surgery, 1965