Clozapine in the treatment of parkinsonian patients with dopaminomimetic psychosis

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Abstract
In a double-blind placebo-controlled study, we evaluated the effects of clozapine (75 to 250 mg/day, mean 170.8) on dopaminomimetic psychosis and parkinsonian disability. Clozapine prevented deterioration of psychosis during the increase of dopaminomimetics in the 3 patients who completed the study. Worsening of parkinsonism occurred in 3 of the 6 patients. In the dosage used, clozapine''s usefulness was limited by its propensity to produce sedation, confusion, and increased parkinsonism.

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