Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists
- 1 October 1988
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 31 (10) , 2034-2039
- https://doi.org/10.1021/jm00118a032
Abstract
3,5-Dimethylbenzo[1,2-c:5,4-c'']dipyrazoles, optionally substituted in the 1-, 7-, and 8-positions, were synthesized from resorcinols. These compounds display affinity for adenosine A1 (rat brain) and A2 (human platelet) receptors. In addition, these compounds reverse contractions of guinea pig tracheal cylindrical segments induced by potassium chloride, histamine, acetylcholine, and 5-hydroxytryptamine, as well as reverse bronchospasm induced by aerosolized histamine in the conscious guinea pig.This publication has 24 references indexed in Scilit:
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