A Protective Role of Pyridoxin Against the Toxic Effects of P

Publisher Website
Google Scholar
Abstract
Mice placed on pyridoxin-free diets were injd. with a single dose of radioactive phosphate (5-6[mu]c./g.). In the animals maintained on a low protein diet (in which symptoms of vit. deficiency did not appear), the admn. of pyridoxin did not affect survival. A marked protection by pyridoxin against the injurious effects of P32 was observed in expts. in which the vit. deficiency had been made more severe by adding a pyridoxin analog (desoxypyridoxin) to the low protein diet, or by increasing the requirements for the vitamin (high protein diets with added cystine or methionine). Differences between the groups receiving and those not receiving pyridoxin were larger than the differences which might result from a simple additive effect of the internal radiation and vit. deficiency.