Effect of truncal vagotomy on acid and pepsin responses to histamine and gastrin in dogs

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Abstract
Acid and pepsin secretion in response to graded doses of histamine and hog gastrin extract was studied before and after truncal vagotomy in dogs with gastric fistulas. Before vagotomy histamine and gastrin produced the same maximal rate of acid secretion. Truncal vagotomy shifted the dose-response curves for both histamine and gastrin to the right; maximal responses were unaltered but larger doses were required. Before vagotomy maximal pepsin response to histamine occurred with a low dose that produced submaximal acid response; higher doses depressed pepsin secretion. Maximal pepsin response to gastrin occurred with a dose that produced nearly maximal acid response. Truncal vagotomy shifted the dose-response curves for pepsin to the right, reduced maximal pepsin response to histamine but did not alter that to gastrin. Truncal vagotomy reduced the responsiveness of the gastric glands to both histamine and gastrin in regard to both acid and pepsin secretion.