MALIGNANT FIBROUS HISTIOCYTOMA OF BONE ASSOCIATED WITH FOCAL HEMANGIOPERICYTOMATOUS PATTERN

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Abstract
A case of malignant fibrous histiocytoma of the tibia of a 49-yr-old farmer was presented. The patient was diagnosed as having malignant hemangiopericytoma by biopsy whereas the amputated material showed a marked pleomorphism representing features of malignant fibrous histiocytoma. Ultrastructurally, undifferentiated mesenchymal cells, intermediate cells between the undifferentiated mesenchymal cells and fibroblastic cells, fibroblastic cells and histiocytoid cells including bizarre giant cells were confirmed in a broad modulating spectrum. The hemangiopericytomatous lesion contained predominantly intermediate cells, the ultrastructure of which bore a close resemblance to that of pericytes, and probably resulted from a differentiation of undifferentiated mesenchymal cells towards the pericyte.