A Proteolytic Enzyme System of the Blood

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Abstract
Staphylokinase, a derivative of Micrococcus aureus culture filtrates, activates dog, human, cat, rabbit and guinea pig, but not rat or bovine profibrinolysins. In the activation of dog profibrinolysin, pH affects the rate, but not the yield of fibrinolysin. Apparently staphylokinase acts as an enzyme, as the fibrinolysin yield is directly dependent upon the quantity of profibrinolysin present and independent of the concn. of staphylokinase over a wide range. However, the rate of fibrinolysin formation is directly dependent upon the staphylokinase concn. No specific salt effects on the rate of activation of profibrinolysin were observed.
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