STUDIES OF STREPTOCOCCAL FIBRINOLYSIS. II. THE INHIBITION OF STREPTOCOCCAL FIBRINOLYSIS BY ANTIFIBRINOLYSIN AND ANTIPROTEASE 1

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Abstract
Dissolution of human plasma clots by fibrinolytic streptococci occurs in 2 stages: (1) conversion of the lytic factor in plasma, by fibrinolysin, into an active protease, and (2) digestion of the clot by the protease. Hence the "antifibrinolysin test" as an index of previous streptococcal infection will be positive when either antifibrinolysin or antipro-tease is present, and also when the plasma contains no lytic factor. The sera of rabbit, guinea pig, horse, cow, and swine contained antiprotease in titers of 1:80 to 1:160. Sera from cases of hemolytic streptococcal infection had antifibrinolysin titers of 1:50 to 1:1400 and antiprotease titers of 1:20 or less. Sera from cases of pneumococcal pneumonia had antifibrinolysin titers of less than 1:5 to 1:640 and antiprotease titers of 1:5 to 1:80. No correlation was found between the antifibrinolysin titer and the antiprotease titer of these sera. Fibrinolysin and antifibrinolysin combine in multiple proportions; at 37 [degree]C. equilibrium is reached in approx. 60 min.

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