The Action of Various Drugs on the Suprarenal Response of the Rat to Total-Body X-Irradiation

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Abstract
A chemical protector, cysteamine (100 mg/kg intraperitoneally), inhibits the second irreversible drop in cholesterol and ascorbic acid which, in the controls, begins on the second day after a total-body exposure to 800 r of X-rays (250 kv). Morphine (20 mg/kg) preceded by Nembutal (pentothal sodium) (20 mg/kg) inhibits the hypothalamo-pltuitary-adrenal response to stress. This combination, prior to total-body irradiation, prevents any change in ascorbic acid and cholesterol values in the rat''s suprarenal during the first 24 hours after irradiation, but does not decrease mortality, nor alter the profound depression of these two values at the third day after irradiation, even if a morphine injection (40 mg/kg) is given daily. It is suggested that the first reversible reaction (during the 24 hours after irradiation) is a simple reaction to the physical stimulus of irradiation acting as a stress. The significance of the second reaction is not clear.

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