ADRENAL RESPONSE TO TOTAL BODY X-RADIATION

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Abstract
The changes in adrenal cholesterol content and adrenal wt. observed after total body x-radiation of white cf rats with either 650r or 900r suggested a considerable adrenal response to these dose levels. Adrenal cholesterol was decreased by some 40-50% as early as 3 hrs. after irradiation . This was followed by a rather gradual rise toward or above normal in the intermediate period. Terminally, the cholesterol content fell precipitously. Although little change in adrenal wt. was noted initially, a progressive increase in wt. (50-100%) was seen in the intermediate and terminal periods after x-radiation with either 650r or 900r. After 200r, there was little change in adrenal activity as judged by these indices of response.