Factors Controlling Calcification in vitro: The Calcium Phosphate Ratio.

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Abstract
Summary 1. Altering the calcium phosphate ratio of calcifying solutions has little effect on the initiation of crystals by an organic matrix in contrast to “spontaneous” precipitation, and the growth of crystals. 2. This observation sheds light on the unresolved argument concerning the old clinical impression that the simple calcium phosphorus product was the best estimate of healing rickets in contrast to that expected theoretically from the calcium phosphate ratio of the salt formed. 3. A difference of this kind would be biologically advantageous since elevation of the serum phosphate would increase the mineralization of seedable matrices more than the tendency toward uncontrolled precipitation. The technical assistance of Pauline Ning is gratefully acknowledged.