Human Leukaemia Associated Antigen (LAA):

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Abstract
Serum LAA is identified as an oncofetal antigen (or antigens) since it is present in fetal liver and in amniotic fluid. Although it is mainly found in patients with proliferative hematological disorders, particularly acute leukemias and chronic myelogenous leukemia, LAA is occasionally present in sera from healthy people. In protein fractionation experiments, LAA behaves as a distinct population of molecules and has the characteristics of an .alpha.2-.beta.-globulin, not carrying any lipids. The origin of LAA in hematological disorders is unknown. Its presence does not correlate with high white blood cell count, although antibody to LAA has been raised in animals injected with blast cells from leukemia patients. LAA is distinct from .alpha.-fetoprotein, and a reaction of immunological non-identity is observed between LAA and ferritin. This is of considerable interest since ferritin was reported to be immunologically closely related to .alpha.2H-globulin which may occur in the same categories of patients as LAA. LAA as defined by the antisera used may be different from .alpha.2H-globulin and ferritin.

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